Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine
The latest research explained the molecular mechanisms of immune response activation following the administration of mRNA vaccine (BNT162b2). Infiltrating lymph node NK cells and CD8 + T cells were the main source of anti-viral IFN- γ
Predicting the mutational drivers of future SARS-CoV-2 variants of concern
Maher and colleagues built a predictive model using epidemiological, immunological, and viral protein modeling data to understand the evolution of SARS-CoV-2. The researchers used the 'EpiScore'
SARS-CoV-2 Omicron-neutralizing memory B-cells are elicited by two doses of BNT162b2 mRNA vaccine
Research data published by Japanese scientists have shown that about 30% of resting memory B cells retain their specificity for Beta and Omicron variants for up to five months
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses
The data published by Polish and German scientists revealed the beneficial effects of acriflavine (ACF) in inhibiting coronavirus replication by blocking the SARS-CoV-2 (PLpro) enzyme.
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
Multi-omic analysis of the immune profile of COVID-19 patients showed a significant role of the AP-1/p38MAPK pathway in disease progression. Proteomic analysis of plasma revealed increased levels of IL-6, IL-8, CCL2, CLEC11A, CCL20, CXCL10 and CCL19
Distinct characteristics of multisystem inflammatory syndrome in children in Poland
An article published in Scientific Reports presents the results of the national register of inflammatory disorders in children (MultiOrgan Inflammatory Syndromes Related Study - MOIS-CoR).